迎校庆报告五：George Washington University Michael A. M

报告题目：NMR Studies of human MID1, an E3 ligase targeting PP2Ac and alpha4 for degradation

报告人：Michael A. Massiah  教授

报告时间：6月26日上午10:00

报告地点：理学院 E211

报告人简 历：

Michael A. Massiah 博士1992年本科毕业于Haverford College，1996年在University of Maryland获博士学位。在Memorial Sloan-Kettering Cancer Center（1996-1997）完成博士后研究之后，1997-2003年在John Hopkins School of Medicine任Research Faculty，2003-2010在Oklahoma State University任助理教授和副教授，2010至今在George Washington University任副教授。目前担任PLOS One编委，NSF和NIH基金评阅人。Michael A. Massiah博士的研究领域集中于：1）核磁共振（NMR）法蛋白质三维结构解析；2）MID1基因的结构与功能；

报告摘要：The research carried out in my lab focuses on understanding the process involved in proper development of the midline region in humans during embryogenesis. We focus on the protein, MID1, for which mutations directly correlate in birth defects along the ventral midline region of males. We have identified that MID1 functions as an ubiquitin E3 ligase. It catalyzes the ubiquitination (covalent attachment of a protein called ubiquitin onto a target) of protein phosphatase 2A (PP2A) and its regulatory subunit alpha4. PP2A is one of the most important enzymes in the cells because it regulates many essentially cellular processes either directly or indirectly. Alpha4 targets and regulates PP2A within specific regions of the cells and within specific cellular pathways. Some of these processes involve mediating cell-cell communication along the midline, tissue-specific cell differentiation, and maturation of immune cells. Alpha4 is a key factor in transforming normal cells into cancerous ones. Understanding how MID1 targets PP2A and alpha4 provides important answers of how specific cellular processes are regulated, and how these processes influence cell cycle.

 I will present a general overview of how we use NMR spectroscopy with biochemical studies to understand the structure and function of MID1 and alpha4.

此次报告是我院庆祝建校建院2014理学论坛之杰出学者第5场，热烈欢迎广大师生参加！

                                                  理学院

 2014年6月23日